Abstract
Objective To investigate the evaluable effect of IGF-1R on the prognosis of uvealmalignant melanoma.Methods The expressions of IGF-1R were detected by immunohistochemistry from 41cases of uveal malignant melanoma.The correlations between IGF-1R expressions and clinicopathologicalparameters were assessed by x2 test.The overall survival rate was determined by Kaplan-Meier curve.High riskfactors affecting the survival time were analysed by Cox's proportional hazard regression model.Results Of41 cases of uveal malignant melanoma, IGF-1R positive expressions were present diffusely in the cytoplasm ofcancer cells in 28 cases (28/41=68.3%).The expression was significantly associated with the cell type,theheight and largest basal diameter of tumor (P <0.05 ),univariate and multivariate analysis of 41 patients, Theexpressions of IGF-1R is a prognostic factor of uveai malignant melanoma.Conclusion The expression ofIGF-1R may be a prognosis factor in human uveal malignant melanoma,which may be helpful to evaluate theclinical curative effect. Key words: IGF-1R,Uveal malignant melanoma,Immunhistochemical teclmique
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