Expression and clinical significance of Hpa and uPA in thyroid carcinoma

Abstract

Objective To study the relationship between heparanase(Hpa), urokinase type plasminogen activator(uPA)expression and lymph node metastasis in thyroid carcinoma. Methods Immunohistochemieal SP method was used to analyze the expression of Hpa and uPA in 113 cases of thyroid carcinoma and 134 cases of benign thyroid nodules. The expression of Hpa and uPA in thyroid carcinoma and its clinical significance were analyzed. Results The positive expression rate of Hpa and uPA in thyroid carcinoma and benign nodular thyroid tissue were 82.30%, 16.42% and 89.38%, 11.19%.The positive expression rate of Hpa and uPA in carcinoma tissues with lymph metastasis and without metastasis were 93.94%, 100% and 65.96%, 74.47%.Expression of Hpa and uPA in thyroid carcinoma group was significantly higher than that of benign thyroid nodules group(P<0.001). The rate of positive expression in lymph metastatic tissues were significantly higher than those in tissue without metastasis(P<0.001). Hpa and uPA expression in thyroid carcinoma tissues was positively correlated(r=0.437, P=0.021). Conclusion The expression of Hpa and uPA is closely related with the occurrence and metastasis of thyroid carcinoma. Key words: Thyroid carcinoma; Benign thyroid nodules; Hpa; uPA