Expression and clinical significance of CyPJ in colorectal carcinoma

Abstract

Objective To investigate the expression and distribution of CyPJ in the colorectal cancer (CRC) and to explore its clinical significance in the development and progression of CRC. Methods The clinical data and surgical specimens of 61 patients with colorectal carcinoma who were treated from May 2015 to April 2016 that were collected from the Department of Gastrointestinal Surgery, Qingdao University Affiliated Yantai Yuhuangding Hospital. Detected by immunohistochemical staining technique in 61 cases of CyPJ protein expression in colorectal carcinoma and paracarcinoma tissues levels. The relationship of the expression of CyPJ with the clinicopathological features of colorectal carcinoma was analyzed using SPSS 23. 0 statistical analysis software. The count data were evaluated using the chi-square test and Fisher exact probability. P<0. 05 was considered as significant difference. Results Expression of CyPJ protein in colorectal cancer tissues is overexpressed and the positive expression of paracarcinoma tissues is visible, but the color lighter. Expression of CyPJ protein is mainly located in the cytoplasm, with little distribution in the nucleus. The positive expression rates of CyPJ protein in the CRC and paracarcinoma tissues were 78. 7% (48/61)and 39. 3% (24/61), respectively, with a significant difference (χ2=19. 520, P 0. 05). Conclusion CyPJ protein is overexpressed in colorectal carcinoma, suggests that it may be associated with the occurrence, development and metastasis of colorectal carcinoma. Key words: Colorectal neoplasms; Development; Metastasis; Cyclophilin J