Abstract
BackgroundmTOR pathway is a cardinal pathway in determination of cell growth and proliferation rate in breast cancer. MethodsWe assessed expression of miR-100 and its putative targets in 60 breast cancer samples compared with adjacent non-cancerous tissues (ANCTs). ResultsmiR-100 expression was significantly decreased in tumoral tissues compared with ANCTs. RAC1 and MTMR3 genes were up-regulated in tumoral tissues compared with ANCTs. RRAGD gene expression was not different between tumoral and ANCTs. We demonstrated associations between miR-100 down-regulation and progesterone receptor status as well as RAC1 over-expression and Her2/neu and Ki-67 statuses. miR-100 expression was correlated with expressions of RAC1, MTMR3 and RRAGD. ConclusionsWe provided further evidences for implication of miR-100 and mTOR pathway in breast cancer pathogenesis.
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