Expression analysis of insulin-like growth factor 1, neutrophil/lymphocyte ratio, and inflammatory factors in children with Mycoplasmal pneumonia

Abstract

Mycoplasma pneumonia (MPP) belongs to atypical pneumonia, which is caused by Mycoplasma pneumonia infection, accounting for 10–40% of children’s community pneumonia. It is more common in children at preschool age. The clinical symptoms of MPP are varied and difficult to cure. The research analyze the expression of inflammatory factors in MPP, neutrophil/lymphocyte ratio (NLR), insulin-like growth factor 1 (IGF1). The aim is to provide relevant basis for treatment and diagnosis of the disease. 40 normal children were selected as the control group. 78 children with MPP were selected as the observation group. The levels of interleukin-6 (IL-6) and interleukin-2 (IL-2) in peripheral blood were detected. Platelet/lymphocyte ratio (PLR) and NLR were tested. IGF1 expression was determined by ELISA. The correlation between IGF1, IL-6, IL-2NLR, PLR and the severity of MPP was analyzed. IL-2, NLR, and PLR significantly increased. The IGF1 in MPP group was lower than control group (P <0.05). IL-6 level in two group was no significant change. NLR, PLR and IL-2 were negatively correlated with IGF1. NLR, IL-2, PLR were positively correlated with MPP severity (P <0.05). NLR, PLR, and IL-2 were upregulated, whereas IGF1 was declined in MPP, which can be used to evaluate the progression of MPP.