Abstract
It was reported that tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) could inhibit the growth of F0-generation fish. However, multi-generation effects of TDCIPP on survival and growth of fish remain unknown. In this study, the effects of TDCIPP on survival and growth in F1 generation zebrafish were evaluated after two-generation exposure. Results demonstrated that TDCIPP inhibited the survival and growth of F1-generation zebrafish at 96 hpf and 30 dpf. Moreover, compared with the F0 generation, two-generation exposure resulted in a greater accumulation of TDCIPP in F1 generation zebrafish, and strongly down-regulated the expression of genes related to the GH/IGF axis (gh, igf1, igf2b) and HPT axis (tshβ). Taken together, for the first time, this study revealed that exposure to TDCIPP for two generations at environmentally relevant concentrations aggravated the adverse effects on growth and survival in zebrafish.
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