Exposure to perfluoroalkyl substances in waste recycling workers: Distributions in paired human serum and urine.

Abstract

Occupational exposure to per- and polyfluoroalkyl substances (PFASs) is an emerging public health concern, because of their potential adverse health effects. In this study, concentrations of 21 legacy and alternative PFASs in paired serum and urine samples collected from 163 workers (from five waste recycling plants) were analyzed. The results showed that the average concentration of 21 PFASs in urine samples (66.6ngmL-1) were higher than in serum (31.3ngmL-1). Concentrations of perfluorocarboxylates (PFCAs) in urine were also considerably higher than perfluorosulfonates (PFSAs), especially for short-chain PFCAs. Demographic factors (such as sex, age, working age, and job assignment) on PFAS exposure were also assessed based on the obtained results. PFAS concentrations in serum samples from males were significantly higher than in females, and working age was positively (p<0.05) associated with most PFAS serum levels. Higher levels of PFAS were found in sorters than in workers with other job assignments, such as managers, suggesting that sorters may be directly exposed to PFASs. Interestingly, perfluorophosphonates (PFPAs) were first to be detected in human urine with >80% detection frequency. The average level of three PFPAs in the serum (7.58ngmL-1) and urine (1.45ngmL-1) samples appeared to be higher in comparison with most PFCAs and PFSAs. Thus, the toxicity of PFPAs in human beings needs to be further studied.