Abstract
Background and Aim: Cardiovascular and respiratory inflammation mediated by cytokines was considered as critical mechanisms in terms of the health effects of ambient air particles exposures. Besides, it is less clear if particles in certain detailed size fractions are more responsible for adverse health effect than others. We investigated in this panel study the exposure to particles of different size fractions and its health effects on cytokines of cardiopulmonary inflammation. Methods: 120 subjects aging from 50 to 65 were recruited through annual physical examination in Peking University Hospital. Each participant has completed 4-6 times clinical visits from Aug. 2013 to Feb. 2015. Biosamples of serum and exhaled breath condensate (EBC) collected during each visit for the measures of cytokines, including: IL-1α, IL-1β, IL2, IL-6, IL-8, TNFα, IFNγ. In total, 589 valid samplers were made for analysis. Hourly averaged number concentration of particles with the size range of 5.6 to 560 nm were measured using Fast Mobility Particle Sizer. We applied linear mixed effect model to estimate the association between biomarkers and particulate size fractions, adjusting for time variation and meteorological parameters. Results: The magnitude of association between cytokines and particle number concentrations was different by particle size, and showed different patterns in EBC and serum samples. For IL-1α, we observed significant associations with particles of all size fractions in serum samples, while in EBC samples the significance only remained for particle size of 200-560 nm. Particles of all size fractions were significantly associated with IL-2 in both EBC and serum samples. Significant adverse effect of particles on IL-6 and IL-8 were only observed in EBC samples. Conclusions: The association between cardiopulmonary inflammation with fine particle concentrations depended on particle size, and showed different patterns in respiratory and cardiovascular system.
Published Version
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