Abstract
ISEE-658 Objective: To assess the relation between organochlorine pesticides (OCPs) measured in maternal serum at approximately 4 weeks postconception (prenatal exposure) and breast milk obtained at approximately 6 weeks postpartum (postnatal exposure) and children's neurobehavioral developmental status at age 24 months. Materials and Methods: Infants (n = 53) born to women (n = 79) recruited before conception for a prospective pregnancy study underwent a standardized 24-month neurodevelopmental assessment (Bayley Scales of Infant Development) administered by a developmental pediatrician. Summary scores included mental (MDI) and psychomotor (PDI) development indexes. Gas chromatography with electron capture was used to quantify the serum samples for OCPs and serum lipids were measured using gravimetric methods. Gas chromatography with high resolution mass spectrometry (GC/HRMS) was used to analyze breast milk samples. OCPs were categorized into tertiles and into structurally similar groupings. Results: (Un)adjusted linear regression analyses showed little effect of prenatal OCP exposure with MDI. Prenatal DDE (9.1 point decrease), aldrin (13.3 point decrease), and hexachlorobenzene (HCB) (15.8 point decrease) levels were associated with decreases in PDI, after adjusting for maternal age and IQ, the home environment, breastfeeding, and serum lipids. No relation was observed for postnatal OCP concentrations and either MDI or PDI. Adjusted regression models including both prenatal and postnatal OCP concentrations displayed similar results to prenatal OCP exposure and decreases in PDI. After adjusting for prenatal and postnatal OCP concentrations, and maternal age and IQ, breast fed children (n = 37) displayed significantly lower MDI scores (cyclodiene insecticides: 19.2 point decrease; organochlorine insecticides: 10.3 point decrease; HCB: 26.1 point decrease; modeled separately). Conclusions: These preliminary findings suggest prenatal OCP exposure may adversely affect neurobehavioral development in toddlers, particularly motor development. In our population, breastfeeding was independently associated with decreased MDI, suggesting that factors present in breast milk other than OCPs (possibly other persistent contaminants) may affect mental development.
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