Abstract
“Juvenile spermatogonial depletion” (jsd) mice are homozygous for the mutated Utp14b gene and have spermatogenic arrest. Several waves of spermatogenesis proceed in the immature jsd mice, but at 6 wks of age spermatogonial differentiation arrests and spermatocyte numbers decline, resulting in the only germ cells being type A spermatogonia by 10 wks. We previously observed that suppression of testosterone or elevation of testicular temperature by cryptorchidization restored spermatogonial and spermatocyte differentiation.
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