Abstract
To The Editor: In the article “Can Vitamin C Prevent Complex Regional Pain Syndrome in Patients with Wrist Fractures? A Randomized, Controlled, Multicenter Dose-Response Study” (2007;89:1424-31), Zollinger et al. studied the prophylactic effect of vitamin C on the prevalence of complex regional pain syndrome in 416 patients with a wrist fracture. They concluded that vitamin C is indeed effective, and they recommended giving 500 mg of vitamin C daily for fifty days to each patient with a wrist fracture to prevent complex regional pain syndrome. Some limitations of this study mentioned in the article include a large selection bias (416 of 2137 eligible patients were enrolled) and a low event rate …
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