Abstract
Background: Bisphenol A (BPA) is an environmental endocrine disrupting chemical affecting public health. So our research aim was to determine whether BPA exposure affects epigenetic mechanisms or not.Methods: We recruited 45 non-smoker females, who were aged 60 years. Participants visited our center 3 times with 1 week interval. On every visit, their urine and blood samples were collected for BPA and epigenome-wide miRNA level measurements, respectively. We evaluated relationships between urinary BPA and miRNA levels. Results: Five miRNAs (miR-1224-3p, miR-138-5p, miR-184, miR-543, and miR-587) were positively associated with BPA exposure (p<0.05 for all 5 miRNAs). The predicted target genes of 5 miRNAs were found to be related with various disease classes including metabolic, cardiovascular, and chemdependency. Furthermore, KEGG pathways on pathway in cancer (hsa05200), PI3K-Akt signaling pathway (hsa04151), and MAPK signaling pathway (hsa04010) in order of precedence were related with BPA exposure. Conclusions: Our study results suggest a potential that BPA exposure modifies epigenetic mechanisms, resulting in a variety of diseases.
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