Abstract
Abstract Funding Acknowledgements Type of funding sources: None. Introduction Air pollution contributes to the premature death of approximately 428,000 citizens of Europe every year. The adverse effects of air pollution can be observed not only in respiratory, circulatory, and nervous systems but also in renal function. Purpose Our goal was to investigate the hypothesis indicating that we can observe the long-term and also short-term impact of air pollution on kidney function. Methods We reviewed medical notes of patients hospitalized between 2007-2016. We used linear, log-linear, and logistic regression models to assess the association between renal function and NO2, SO2, and PMs. Results are reported as beta (β) coefficients and odds ratios (OR) for an increase in interquartile range (IQR) concentration with 95% confidence intervals (CI). Results 3,554 patients were included into the final analysis. The median age was 66 (IQR 15) and men were in the majority (53.2%, N = 1891). Chronic kidney disease (CKD) was diagnosed in 21.5% (N = 764). The long-term increase in annual average concentration of PM2.5 (OR for IQR increase = 1.07; 95% CI 1.01 – 1.15, P = 0.037) and NO2 (OR for IQR increase = 1.05;95% CI 1.01 – 1.10, P = 0.047) resulted in an increased number of patients with CKD. In short-term observation the IQR increase in weekly PM2.5 concentration was associated with a 2% reduction in eGFR (OR = 0.98, 95%CI 0.97 – 0.99, P = 0.03) Conclusions The effects of air pollution on renal function were observed. Long- and short–term exposure to elevated air pollution levels was associated with a decrease in eGFR. The main pollutant affecting the kidneys was PM2.5.
Highlights
Air pollution contributes to the premature death of approximately 428,000 citizens of Europe every year
In short-term observation the interquartile range (IQR) increase in weekly PM2.5 concentration was associated with a 2% reduction in estimated glomerular filtration rate (eGFR) (OR=0.98, 95%confidence interval (CI) 0.97 – 0.99, P=0.03)
Long- and short–term exposure to elevated air pollution levels was associated with a decrease in eGFR
Summary
Air pollution contributes to the premature death of approximately 428,000 citizens of Europe every year. In recent years it has been established that air pollutants associated with the harmful effect on human health are particulate matter with a diameter of 2.5 mm or less (PM2.5), particulate matter with a diameter of 10 mm or less (PM10), sulfur dioxide (SO2), and nitrogen dioxide (NO2) [1]. Some of these components are formed directly as a result of fuel burning, while others emerge as a result of photochemical reactions that occur under the influence of ultraviolet radiation in the air. The mentioned above processes lead to oxidative stress which is widely acknowledged as a factor for vascular dysfunction [14,15,16]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have