Abstract
1. 1. Surface materials have been removed by chelant or by trypsin treatment from normal BHK 21/C13 cells ad from the same cells transformed by polyoma and Rous sarcoma viruses. 2. 2. These materials, labelled by various radioactive precursors, have been analysed by chromatographic and electrophoretic techniques. 3. 3. The results suggest that the material removed from the cell surface is a mixture of glycopeptides and glycosaminoglycans. 4. 4. A sulphated glycosaminoglycan component (tentatively identified as heparan sulphate) is removed from the transformed cells in a significantly lower relative amount as compared with the control untransformed cells. 5. 5. A possible role of this surface polyanionic component as a negative control element of cell growth is suggested and discussed.
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