Abstract
The addition of albumin to a suspension of plasma membranes isolated from rat epididymal fat cells increases both the initial binding rate and the maximal specific binding of prostaglandin E 2 to these membranes. The presence of albumin affects neither the dissociation rate of bound prostaglandin E 2 nor its dissociation constant. The results indicate that the interaction of albumin with the isolated membranes exposes latent prostaglandin-binding sites. Albumin fails to alter the specific binding of prostaglandin E 2 to membranes isolated from frog erythrocytes or from rat peritoneal fat cells. These results indicate that the effect of albumin on the specific binding of prostaglandin E 2 characterizes a specific molecular property of the prostaglandin receptors in rat epididymal adipocytes.
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