Abstract
Rats and hamsters were exposed eight hours/day for 56 consecutive days to automotive emissions containing increased concentrations of Mn particulate which resulted from the use of a fuel additive, methylcyclopentadienyl manganese tricarbonyl. The exhaust gases were generated by using a 1972 Chevrolet 350 CID engine dynamometer system. The exhaust was diluted and the average concentration of Mn particulate in the irradiated animal exposure chambers was approximately 117 μg/m 3. No gross changes in general condition or appearance were observed in any of the animals. Microscopic examination of tissues from the animals showed changes related to the exhaust emissions and no changes were found which could be solely attributed to the presence of Mn or MMT. Mn concentrations in the tissues from exposed animals were generally elevated.
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