Exposure, hazard, and vulnerability all contribute to Schistosoma haematobium re-infection in northern Senegal.

Andrea J Lund,David López-Carr,Susanne H Sokolow,Chelsea L Wood,Gilles Riveau,Sofia Ali,Anne-Marie Schacht,Assane Fall,Giulio A De Leo,Andrew Chamberlin,Nicolas Jouanard,M Moustapha Sam,Isabel J Jones,Simon Senghor,Raphael Ndione,Alioune Badara Sy,Poppy H L Lamberton

doi:10.1371/journal.pntd.0009806

Abstract

Infectious disease risk is driven by three interrelated components: exposure, hazard, and vulnerability. For schistosomiasis, exposure occurs through contact with water, which is often tied to daily activities. Water contact, however, does not imply risk unless the environmental hazard of snails and parasites is also present in the water. By increasing reliance on hazardous activities and environments, socio-economic vulnerability can hinder reductions in exposure to a hazard. We aimed to quantify the contributions of exposure, hazard, and vulnerability to the presence and intensity of Schistosoma haematobium re-infection. In 13 villages along the Senegal River, we collected parasitological data from 821 school-aged children, survey data from 411 households where those children resided, and ecological data from all 24 village water access sites. We fit mixed-effects logistic and negative binomial regressions with indices of exposure, hazard, and vulnerability as explanatory variables of Schistosoma haematobium presence and intensity, respectively, controlling for demographic variables. Using multi-model inference to calculate the relative importance of each component of risk, we found that hazard (Ʃwi = 0.95) was the most important component of S. haematobium presence, followed by vulnerability (Ʃwi = 0.91). Exposure (Ʃwi = 1.00) was the most important component of S. haematobium intensity, followed by hazard (Ʃwi = 0.77). Model averaging quantified associations between each infection outcome and indices of exposure, hazard, and vulnerability, revealing a positive association between hazard and infection presence (OR = 1.49, 95% CI 1.12, 1.97), and a positive association between exposure and infection intensity (RR 2.59-3.86, depending on the category; all 95% CIs above 1). Our findings underscore the linkages between social (exposure and vulnerability) and environmental (hazard) processes in the acquisition and accumulation of S. haematobium infection. This approach highlights the importance of implementing both social and environmental interventions to complement mass drug administration.

Highlights

When a natural hazard like a flood or hurricane is imminent, risk managers and first responders must account for the exposure and vulnerability of affected populations, conditions and processes that are dynamic in both space and time [1]
When comparing children whose households relied on surface water for multiple household tasks to those who relied on surface water for no household tasks, we found an almost nine-fold increase in the odds of infection with a confidence interval entirely above the null value of 1 (Categorical surface water use [2 activities vs 0]; Odds ratios (OR) = 8.67, 95% confidence intervals (95% CIs) 1.67, 45.60)
Given the shortcomings of previous studies on water contact and snail ecology, we found that accounting for the spatial relationship between people and the environmental hazard improved the fit of S. haematobium presence models

Summary

Introduction

When a natural hazard like a flood or hurricane is imminent, risk managers and first responders must account for the exposure and vulnerability of affected populations, conditions and processes that are dynamic in both space and time [1]. Wildlife biodiversity–representing the size of the natural reservoir of potentially zoonotic pathogens–is used as a proxy for spillover risk [7]. While these measures reflect important components of pathogen transmission, their focus on the source of the disease-causing agent overlooks the socio-ecological processes that connect those infectious agents with susceptible people, thereby facilitating transmission and determining risk. Exposure and vulnerability reflect the roles of human behavior and social structures in transforming hazard into risk: exposure describes contact between a person and a pathogen (e.g., exposure to a hazard), while vulnerability determines the extent to which people can anticipate, adapt to, and potentially mitigate the impacts of infection [6, 9]. We aimed to quantify the contributions of exposure, hazard, and vulnerability to the presence and intensity of Schistosoma haematobium re-infection

Objectives

Methods

Results

Discussion

Conclusion