Abstract
The Exponentially Modified Gaussian (EMG) function is fitted to a variety of typical peaks from isocratic HPLC, to assess its validity for peak characterization. This model has previously been applied, but with simplifying assumptions, allowing estimation of peak parameters from simple “front and rear” half-width measurements. The full EMG function is employed in this work. The results of the simplified approach have been compared to the EMG fitted results. Comparison is also made to fitted Gaussian functions. Results show that the EMG function is a good model for typical LC peaks, under a range of conditions, and that the simplified approaches give close correlation for a range of peak assymetries.
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