Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies.

Maria Vall,Natalia Ferraz,Teresa Zardán Gómez de la Torre,Ocean Cheung,Maria Strømme

doi:10.3390/molecules24091820

Abstract

Salicylic acid (SA) has for a long time been used to treat various skin disorders due to its anti-inflammatory, bacteriostatic, and antifungal properties. In the present work, mesoporous magnesium carbonate (MMC), a promising drug carrier, was modified with 3-aminopropyl-triethoxysilane to enable loading of SA. The amine modified MMC (aMMC) was successfully loaded with 8 wt.% of SA via a solvent evaporation method. SA was later completely released from the carrier in less than 15 min. Furthermore, the cytotoxicity of the functionalized material was evaluated. aMMC was found to be non-toxic for human dermal fibroblast cells with particle concentration of up to 1000 µg/mL when exposed for 48 h. The presented results form the basis of future development of aMMC as a potential carrier for SA in dermatological applications.

Highlights

Salicylic acid (SA) has been used as a peeling agent in order to treat skin disorders for more than 2000 years [1]
After loading amine modified MMC (aMMC) with SA, the surface area and pore volume were reduced even further. aMMC–SA still remained highly porous, which is an indication that SA was loaded inside the porous structure rather than on the surface
Salicylic acid was successfully loaded in aMMC to form a formulation containing 8 wt.% of the drug. This drug was subsequently released from aMMC in vitro in less than 15 min

Summary

Introduction

Salicylic acid (SA) has been used as a peeling agent in order to treat skin disorders for more than 2000 years [1]. SA blocks the in vivo production of pro-inflammatory prostaglandins, giving it anti-inflammatory properties, and it has bacteriostatic as well as fungicidal properties [3,4,5] These properties make SA useful as a peeling agent for patients suffering from acne, a common skin disease that occurs when hair follicles become plugged with dead skin cells and sebum [6]. It is used when treating post-acne erythema and hyperpigmentation of skin, which is a consequence of acne. SA has been loaded into different porous matrices, in MCM-41 and SBA-15 [11] and in halloysite nanotubes functionalized with dendrimers [12]

Methods

Results

Conclusion