Abstract
Background Spleen Tyrosine Kinase (SYK) is a key activator of signaling pathways downstream of multiple surface receptors implicated in asthma. SYK function has been extensively studied in Last cells downstream of the high-affinity IgE receptor (FceR1). Most studies evaluating SYK function in preclinical models have relied on poorly selective compounds, anti-sense oligonucleotides, or SYK knockout mice. Here we describe the characterization of SYK mechanism in multiple in vivo model settings.
Highlights
Spleen Tyrosine Kinase (SYK) is a key activator of signaling pathways downstream of multiple surface receptors implicated in asthma
We describe the characterization of SYK mechanism in multiple in vivo model settings
Materials and methods The effect of SYK inhibitor MRK-A on allergic airway responses was evaluated in IgE-mediated tracheal extravasation in rat, Brown Norway Ova rat models of allergic inflammation and the sheep inhaled ascaris allergen challenge model
Summary
Michael Caniga, Janice D Woodhouse, Alan Wilhelm, Malgorzata A Gil, Yanlin Jia, Hongshi Yu1, Stella Vincent, Richard Miller, Gissela Lieber, Xiomara Fernandez, Richard Chapman, Robbie McLeod, Lily Y Moy, Nancy Kelly, Emily Hickey, Michael A Crackower, Thomas Miller, William M Abraham, Milenko Cicmil1*
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