Abstract
Atopic asthma is a hypersensitive reaction that occurs on exposure to allergens mediated by immunoglobulin E. Environmental, genetic and immunological factors concurrently influence the onset, development and severity of the disease characterized by wheezing, bronchospasm, cough and airway remodeling. Human gut microbiota is a complex, dynamic and diverse environment that regulates physiological mechanisms and prevents occurrence of disorders. The role of gut microbiota in atopic asthma has been established due to its effects at the immunological and histological levels. Composition of microbiota in the case of atopic asthma has been found to vary with age, health status, maternal effect, usage of antibiotics and method of delivery. Therapeutics that can modify the microbiota including probiotics, prebiotics and synbiotics are implicated in treatment of atopic asthma. Furthermore, traditional medicine-based interventions are also being explored among which curcumin has proven to be highly efficacious. This review provides a comprehensive view on factors, diagnosis, treatment, association of gut microbiome and remedies for asthma.
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