Abstract
Purpose: Osteoarthritis (OA) is a debilitating disease of the joints involving progressive cartilage degeneration, with no disease-modifying therapy available. Chondrocytes, the cellular component of cartilage, regulate cartilage homeostasis by modulating matrix turnover via secretion of proteoglycans and collagen as well as matrix-degrading enzymes. In OA, articular chondrocytes acquire an aberrant phenotype where they undergo hypertrophic differentiation with increased production of matrix-degrading enzymes leading to cartilage degeneration.
Published Version
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