Abstract
AbstractA new class of chiral sulfonium salts, derived from L‐ and D‐methionine, has been designed and successfully employed in our laboratories for the diastereoselective synthesis of glycidic amides. The epoxy amides obtained were converted cleanly into 1,2‐difunctionalized products through oxirane ring‐opening reactions with different types of nucleophiles. The resulting ring‐opened products represent valuable and useful building blocks for the synthesis of different bioactive products. Thus, the expedient synthesis of clavaminol H as well as the synthesis of key precursors for other bioactive compounds, for example, polyketide‐derived natural products, have been achieved, demonstrating the synthetic efficiency and utility of this chemistry.
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