Abstract
Background: Microalgal extracts are an important source of bioactive compounds with antioxidant and anti-inflammatory properties that can be used in cosmetics. The microalgae Phaeodactylum tricornutum (PT) is known for its high content of omega-3 fatty acids, which are known to attenuate inflammation. Here, we explore the effects of aqueous microencapsulated extract of PT on lipopolysaccharide (LPS)-stimulated normal human dermal fibroblasts (NHDF) to underline its application as an active ingredient in cosmetics. Methods: We assessed cell viability using MTT assay, so as to target any potential cytotoxicity of the extract. Moreover, with the aid of RT-qPCR, we studied the transcript accumulation of genes involved in cell antioxidant response, cell proliferation, and inflammation. Results: Our results revealed that the hydrolyzed rice flour-encapsulated (HRF) PT extract promotes anti-inflammatory and antioxidant response, increasing cell proliferation in NHDF cells. Conclusions: Our data indicate a promising use of HRF-encapsulated PT extract in cosmetics by reducing skin inflammation.
Highlights
Skin is the main target of inflammation, as it is exposed to various environmental stress factors [1]
Fucoxanthin derived from Phaeodactylum tricornutum (PT) was shown to exhibit pro-inflammatory properties in vitro, and it can serve as a key candidate in the development of potential therapeutic agents for inflammatory diseases as well as neurodegenerative diseases caused by NFkB and NLRP3 inflammasome activation [10]
We present the anti-inflammatory effects of the natural based extract, the hydrolyzed rice flour-encapsulated (HRF)-encapsulated Phaeodactylum tricornutum extract in LPS-treated human fibroblasts in an attempt to be used in future cosmetic formulations as an anti-inflammatory agent
Summary
Skin is the main target of inflammation, as it is exposed to various environmental stress factors [1]. Inflammation, which is an immune-related process, is associated with the development of skin diseases [4,5,6], while current research is seeking to discover new natural anti-inflammatory agents. Microalgae could be a natural source of anti-inflammatory compounds. PT is a rich source of mono-unsaturated fatty acids such as palmitoleic acid (C16:1n7), minerals, as well as carotenoid (e.g., fucoxanthin) [11]. A recent study presented the anti-inflammatory effects of PT extract on human mononuclear cells, underlining the potential health benefits of its usage in both animal and human nutrition [14]. Microalgal extracts are an important source of bioactive compounds with antioxidant and anti-inflammatory properties that can be used in cosmetics. Results: Our results revealed that the hydrolyzed rice flour-encapsulated (HRF) PT extract promotes anti-inflammatory and antioxidant response, increasing cell proliferation in NHDF cells. Conclusions: Our data indicate a promising use of HRF-encapsulated PT extract in cosmetics by reducing skin inflammation
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