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Abstract
Exploring the potentials of selected bioactive compounds isolated from Piper guineense Schumach. & Thonn. leaf toward identification of novel pfDHFR and pfDHODH inhibitors as antimalaria agents
Highlights
Malaria is endemic in over 100 nations as it is caused by Plasmodium parasites
This study was designed to assess the molecular relations obtainable between piperine, pipercide, and piperlongumine compounds isolated from Piper guineense Schumach. & Thonn. leaf and targeted receptor linked to malaria Plasmodium falciparum dihydrofolate reductase and Plasmodium falciparum dihydroorotate dehydrogenase for antimalarial properties
The top interaction poses for the piperine, pipercide, piperlongumine, and pyrimethamine having higher binding interaction were spotted having a deep association with the binding site of Plasmodium falciparum dihydrofolate reductase (pfDHFR) and Piperine Pipercide Piperlongumine Pyrimethamine pfDHFR docking score (Kcal/mol) −8.3 −7.5 −7.7 −7.8
Summary
Malaria is endemic in over 100 nations as it is caused by Plasmodium parasites. Plasmodium falciparum is communicated solely via the bites of female Anopheles mosquito. If not managed well within 24 hours of infection, it can lead to austere sickness, resulting in death. The prevalence of malaria has been the main cause of death in adults and infants worldwide. Recent estimates show that about 228 million cases occurred worldwide in 2018 with the increasingly prominent in regions like Africa and Asia (World Health Organization, 2019). In Nigeria, malaria is the leading cause of death in both infants and adults as Nigeria accounts for 25% of the malaria cases worldwide
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