Abstract
This study explores the use of chemical epigenetic modifiers to enhance the production of bioactive molecules in the dinoflagellate Amphidinium carterae. It was selected for its known ability to produce amphidinols with various pharmacological and agro-industrial applications. Growth inhibition, photosynthetic yield reduction, and stress-related variables were observed in response to different treatments using 5-azacitidine, hydroxamic suberoylanilide acid, metyrapone, tricyclazole, sodium butyrate, and jasplakinolide. Although no evidence of amphidinols overproduction was found, hydroxamic suberoylanilide acid and tricyclazole showed potential for stimulating the synthesis of antioxidant carotenoids such as peridinin and their derivatives. An increase of around 200% and 170% relative to control was observed at the highest non-lethal concentration. More research is required to elucidate the mechanisms underlying this response and to optimize production conditions. This pioneering research opens up new avenues for the biotechnological exploitation of dinoflagellate microalgae.
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