Abstract
The objective of the current paper was to screen potential of electrospray technique for synthesis of cocrystals from a most challenging caffeine (CA)/maleic acid (MA) pair. Additionally, the influence of solvent properties on the formation of a cocrystal form was also investigated. CA and MA were dissolved in a sufficient amount of methanol, ethyl acetate, acetone, and water separately so as to obtain 1:1 and 2:1 equimolar ratios. The prepared solutions were electrosprayed at a voltage of 20 kV. The cocrystals formed from these solvents with diverse physicochemical properties were analyzed by X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. Methanol, acetone, ethyl acetate, and water have H-bond acceptor/donor (HBA/HBD) values of ≥0.5, 0, 0, and ≥0.5, respectively. CA/MA in 1:1 form I and II were formed predominantly from methanol, ethyl acetate, and acetone regardless of the starting composition. It was observed that, in spite of having zero HBA/HBD valu...
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