Exploring the Potential of Echinococcus Granulosus Antigens in Immunotherapy for Cancer

Abstract

Background: Echinococcus granulosus, intrigues researchers due to its unique biology and immunogenicity. Recent studies show a negative relationship between echinococcosis incidence and cancer progression, emphasizing significant similarities between E. granulosus and cancer antigens. This article will review the anti-cancer effects of E. granulosus antigens and their application in cancer immunotherapy. Main Body: It begins with an introduction, highlighting the significance of E. granulosus antigens in contemporary cancer treatment. Subsequently, an overview of hydatid cysts, the source of these antigens, elucidating their structure and immunogenic properties is provided. Our review extends to the interactions between echinococcosis and both the innate and acquired immune systems, shedding light on the mechanisms involved. We delve into the intriguing connections between echinococcosis and cancer, exploring the direct and indirect anti-cancer effects of these antigens and their potential in cancer immunotherapy. To offer a balanced perspective, we also weigh the pros and cons of using E. granulosus antigens in cancer therapy. Conclusion: In conclusion, the promising attributes of E. granulosus antigens, as highlighted throughout this review, suggest a bright future for their utilization in cancer therapy. Their ability to trigger potent immune responses and target cancer cells holds great potential for the development of effective and tailored therapies, offering new hope for improved cancer treatment outcomes. Further research and clinical trials are needed to fully realize the potential of E. granulosus antigens in the field of cancer immunotherapy.