Abstract
There is considerable interest in the potential therapeutic application of mesenchymal stem cells (MSC) in a wide variety of clinical settings. While initial studies focused on the bone marrow origin of MSC, burgeoning data now demonstrate that cells with many of the phenotypic and functional properties of their counterparts in bone marrow are also present in a range of other tissues such as adipose tissue and teeth. A significant barrier to the study of MSC biology is the lack consensus regarding specific markers of MSC facilitating their identification and isolation coupled with the current lack of knowledge regarding the precise ontological origin of MSC in the post natal animal. However one observation about which many investigators are in accord is the perivascular location of putative MSC which has led to the proposal that the pericyte represents the cellular identity of MSC. This presentation will focus on recent data in the mouse model in which transcriptional profiling of highly purified, prospectively isolated MSC and vascular endothelial cells from the bone marrow has allowed us to begin to explore the interaction between MSC and their vascular niche.
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