EXPLORING THE NEXUS: METHAMPHETAMINE-INDUCED PSYCHOSIS, CO-MORBID MENTAL DISORDERS, AND ASSOCIATED RISKS AMONG DEPENDENT INDIVIDUALS IN TERTIARY CARE HOSPITAL OF PESHAWAR

Abstract

Objective: This study examined the risk of lifetime and present methamphetamine-induced psychosis in dependentindividuals. The relationship between methamphetamine-induced psychosis and mental co-morbidity was examined.Study design : A Cross-sectional studyDuration and place of study : tertiary care hospital of Peshawar from January 2022 to January 2023Methods: This Cross-sectional study done simultaneously at a Peshawar Tartary care hospital from January 2022to January 2023. The Mini International Neuropsychiatric Interview (M.I.N.I.) was used to interview DSM-IV-diagnosed methamphetamine users for psychosis and other Axis I psychiatric disorders. Social demographics and druguse history were acquired via interviews or medical records.Results: There was a history of psychotic symptoms in 65 (45.4% of the total) participants, and 23 (15.6% ofthe total) patients at the present time. After adjusting for other covariates, there was a substantial association betweenheavy methamphetamine use, childhood methamphetamine-induced psychosis, and co-morbid major depressive disorder(n-24, 16.2%), bipolar disorder (n-6, 5.8%), and antisocial personality disorder (n-14, 10.8%). The only variableslinked to present psychosis were major depressive illness (n-6, 5.8% of the population) and antisocial personalitydisorder (n-4, 4.2% of the population).Conclusion: this study sheds light on the interplay between methamphetamine use, psychosis, and co-morbid mentaldisorders. Early detection and integrated treatment approaches are vital for mitigating the adverse effects of substanceabuse and improving mental health outcomes in affected individuals.Keywords: Methamphetamine, Psychosis, Co-morbidity, Dependent individuals, Mental disorders