Abstract
Background: Physical activity (PA) protects against cancer and enhances cancer survivorship. Given high inactivity rates nationwide, population-level physical activity facilitators are needed. Several authoritative bodies have recognized that zoning and planning helps create activity-friendly environments. This study examined the association between activity-friendly zoning, inactivity, and cancer in 478 of the most populous U.S. counties.Methods: County geocodes linked county-level data: cancer incidence and smoking (State Cancer Profiles), inactivity (Behavioral Risk Factor Surveillance System), 11 zoning measures (compiled by the study team), and covariates (from the American Community Survey and NAVTEQ). For each zoning measure, single mediation regression models and Sobel tests examined whether activity-friendly zoning was associated with reduced cancer incidence, and whether inactivity mediated those associations. All models were clustered on state with robust SEs and significance at the P < 0.05 level.Results: Zoning for crosswalks, bike-pedestrian connectivity, and bike-pedestrian trails/paths were associated with reduced cancer incidence (β between -0.71 and -1.27, P < 0.05), about 1 case per 100,000 for each 10 percentage-point increase in county population exposure to zoning. Except for crosswalks, each association was mediated by inactivity. However, county smoking attenuated these results, with only crosswalks remaining significant. Results were similar for males (with zoning for bike-pedestrian connectivity, street connectivity, and bike-pedestrian trails/paths), but not females, alone.Conclusions: Zoning can help to create activity-friendly environments that support decreased inactivity, and possibly reduced cancer incidence.Impact: Given low physical activity levels nationwide, cross-sectoral collaborations with urban planning can inform cancer prevention and public health efforts to decrease inactivity and cancer. Cancer Epidemiol Biomarkers Prev; 26(4); 578-86. ©2017 AACRSee all the articles in this CEBP Focus section, "Geospatial Approaches to Cancer Control and Population Sciences."
Highlights
Cancer incidence continues to rank among one of the top 10 leading causes of death in the United States and accounts for 23% of all deaths [1,2], but cancer-related deaths are declining
Zoning for crosswalks, bike-pedestrian connectivity, and bike-pedestrian trails/paths were associated with reduced cancer incidence (β between −0.71 and −1.27, P
The number of cancer survivors is continuing to grow, with the number of people who have lived 5 years or more after their cancer diagnosis projected to increase approximately 37% to 11.9 million [3]. These simultaneous trends of increasing cancer incidence and decreasing cancer mortality have contributed to a need for more focused research on modifiable lifestyle factors, including physical activity (PA) levels, that can protect against cancer and improve postdiagnostic quality of life
Summary
Cancer incidence continues to rank among one of the top 10 leading causes of death in the United States and accounts for 23% of all deaths [1,2], but cancer-related deaths are declining. The number of cancer survivors is continuing to grow, with the number of people who have lived 5 years or more after their cancer diagnosis projected to increase approximately 37% to 11.9 million [3]. These simultaneous trends of increasing cancer incidence and decreasing cancer mortality have contributed to a need for more focused research on modifiable lifestyle factors, including physical activity (PA) levels, that can protect against cancer and improve postdiagnostic quality of life. This study examined the association between activity-friendly zoning, inactivity, and cancer in 478 of the most populous U.S counties
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
