Exploring the Insilico Properties and Docking Studies of Sudarshan Churna for Anti-Sars-CoV-2 Activity

Abstract

The origin and practice of ayurvedic preparations in India dates back centuries ago. These preparations are used to treat a variety of conditions from common cold to genetic disorders. Antiviral activities of Phyllanthus niruri, Glycyrrhiza glabra, Eclipta alba, Allium sativum, Ocimum sanctum and many other plants are researched for potent antiviral agents. SARS CoV-2 a strain of coronavirus causing COVID19 emerged as a global pandemic affecting millions of people. Ayurvedic preparations like Kabasura Kudineer, Chavanprash and Nilavembu Kudineer are being tested for their antiviral and immunity boosting properties. Objective: Sudarshan churna is an ayurvedic preparation. It is a mix of many herbal powders. It is in use in India since many centuries. Swertia chirata, a potent antiviral herb is the main ingredient of Sudarshan churna. Apart from it, this highly effective product contains many antiviral and antibacterial herbs such as Giloya, turmeric neem, Parpata etc. This study aims to explore the insilico properties and molecular docking studies of this preparation against COVID19. Method: The druglikeness of 202 compounds were evaluated and molecular docking for these compounds were performed against SARS CoV-2 proteins by insilico techniques Results: 177 compounds exhibited druglikeness. Good docking results were observed with 45 ligands against 6M0J and 55 ligands against 6LU7 protein.Conclusion: The active constituents of Sudarshan Churna have good anti SARS CoV-2 activity and can serve as a lead against the SARS CoV-2.