Abstract
Exploring the heterogeneity of use-dependent sodium channel inhibitor drugs. II: Drugs described by the modulated receptor hypothesis (MRH) and/or the guarded receptor hypothesis (GRH)
Highlights
13th Scientific Symposium of the Austrian Pharmacological Society (APHAR)
Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT) Ernst Singer and Thomas Griesbacher Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here http://www.biomedcentral.com/content/pdf/1471-2210-7-S2-info.pdf
We assumed that the two hypotheses are not mutually exclusive, and speculated that both altered affinity and altered accessibility to the inactivated state can be expressed as changes in association and dissociation rates upon conformational transition
Summary
13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT) Ernst Singer and Thomas Griesbacher Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here http://www.biomedcentral.com/content/pdf/1471-2210-7-S2-info.pdf . Address: Institute of Experimental Medicine, Budapest, Hungary Email: Arpad Mike* - mike@koki.hu * Corresponding author from 13th Scientific Symposium of the Austrian Pharmacological Society (APHAR).
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