Exploring the functional connectivity characteristics of brain networks in post-stroke patients with global aphasia: a healthy control based resting-state fMRI study.

Abstract

In this study, resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the characteristics of functional connectivity of brain networks in patients with post-stroke global aphasia (PGA). PGA patients hospitalized in Wuxi Tongren Rehabilitation Hospital during their subacute stage were selected as a case group, and healthy volunteers with matching age, sex, and education level were selected as healthy controls (HCs). rs-fMRI scans were performed to compare the differences of functional connectivity in resting-state networks (RSNs) and in the whole brain between the two groups. A total of 11 patients with PGA and 11 HCs were included in this study. PGA patients showed decreased inter-hemispheric connectivity of homologs within the sensorimotor network (SMN), salience network, and language network. In the analysis of the whole brain functional connections, PGA patients exhibited both inter-hemispheric and intra-hemispheric hypoconnectivity when compared with HCs. However, they exhibited some stronger connections than HCs between the language network and cerebellar network, which may indicate compensatory mechanisms. Using rs-fMRI to research differences in the functional connectivity of brain networks in post-stroke global aphasia will help us further understand it's neurological mechanism and provide an important basis for the accurate selection of therapeutic targets in the future to promote better recovery of language function.