Exploring the effects of free fatty acids in rat serum on the coronary atherosclerotic plaque formation by the CT projection measurement results of compression sensor

Abstract

In order to investigate the effect of free fatty acids in serum on the formation of atherosclerotic plaque in coronary arteries, firstly, the atherosclerotic coronary artery rat model was constructed to detect the changes of body weight and body temperature in the control group and the experimental group. Then the serum of the rats was extracted to detect the difference of triglyceride, total cholesterol, fasting blood glucose, low density lipoprotein, high density lipoprotein, insulin and free fatty acid. The content differences of saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids between the two groups were detected. Then, the difference of contents of serum NO, endothelin – 1 (ET-1), angiotensin II (AngII), ox-low-density lipoprotein (ox-LDL), interleukin-6 (IL-6) and tumor necrosis factor – α (TNF-α) in the rat model after 0 days of feeding and 150 days of feeding was detected by enzyme-linked immunosorbent assay. And the rat coronary artery tissue and myocardial histopathological sections were made for analysis. Finally, based on compression sensor technology, CT imaging results were used to analyze the effects of different fatty acid contents on the carotid intima-media thickness and arterial plaque in rats. The results showed that the weight, body temperature, triglyceride and other indexes in the experimental group were significantly higher than those in the control group at 150d (P < 0.05). The content of NO gene was significantly higher than that of the control group (P < 0.05). There were pathological injury, inflammation of coronary artery and myocardial tissue in the experimental group. The correlation analysis showed that the content of free fatty acids was correlated with carotid intima-media thickness and arterial plaque. Therefore, free fatty acids can be a risk factor for the formation of atherosclerotic plaque in coronary arteries.