Exploring the dynamic relationship: Changes in photoplethysmography features corresponding to intracranial pressure variations

Abstract

This study investigates the relationship between photoplethysmography (PPG) signals and intracranial pressure (ICP) through two primary hypotheses. Firstly, it examines whether alterations in PPG-derived features correspond to changes in ICP levels. Secondly, it explores whether these changes are more pronounced in features derived from “cerebral” long-distance near-infrared (NIR) PPG data compared to “extracerebral” short-distance NIR-PPG data. A clinical dataset comprising synchronised measurements from a non-invasive NIR-PPG sensor and an intra-parenchymal, invasive ICP pressure probe across 27 patients was compiled. From this dataset, two distinct datasets were derived, comprising short and long-distance NIR-PPG data. Within each dataset, 141 features were extracted for every one-minute window of non-invasive NIR-PPG data, including original, first derivative, and second derivative features. Correlation analysis using Spearman’s correlation and a non-parametric Kruskal–Wallis test across the range of ICP values were conducted to evaluate the relationship between features and ICP levels. The results support both hypotheses, showing significant correlations between the features and ICP levels. Specifically, 77.30% and 79.43% of features significantly correlated (p<0.05) with the label in distal and proximal datasets, respectively. Kruskal–Wallis analysis revealed that 81.56% and 75.89% of features significantly changed (p<0.05) across ICP groups 0–10, 10–20, and 20–39 mmHg. The distal dataset yielded a meaningfully higher absolute average correlation coefficient of all features and significantly correlated features in-comparison to the proximal dataset of 25.76% and 24.24% respectively. These findings indicate NIR-PPG features are reflective of variations in ICP.