Abstract
The Journal of the Ceylon College of Physicians (JCCP) is a peer-reviewed, open access journal published bi-annually by the Ceylon College of Physicians (CCP) in the last week of June and December.The objective of the Journal is to promote good clinical practice and influence policy making across the medical world through publication of original research and peer reviewed articles on current issues and to foster responsible and balanced debate on issues that affect medicine and health care in Sri Lanka. Contributions to the JCCP reflect its national and multidisciplinary readership and include current thinking across a range of medical specialties.
Highlights
Pathogenic RNA viruses such as dengue, yellow fever, influenza, Ebola, hepatitis C, SARS-1 and more recently SARS-nCoV-2, have posed significant threats to human health and global economy through epidemics and pandemics.[1,2,3] Arguably, as a group, these are the most significant contemporary threat to human health in the domain of infectious diseases.[4]
We demonstrated that the origin of hepatitis C virus (HCV) subtype 1a infections was earlier than that of subtype 3a in both continents and that epidemics of both subtypes saw an exponential increase of infections between 1955-1975 before slowing and stabilising in the 1990s
The full genome amplification method developed by us has been used by other teams to design similar assays for other viruses such as enteroviruses and SARS-nCoV-2. 7,38 The findings from above mentioned projects had a significant knowledge impact on understanding HCV pathogenesis, predicting outcomes and designing elimination strategies
Summary
Pathogenic RNA viruses such as dengue, yellow fever, influenza, Ebola, hepatitis C, SARS-1 and more recently SARS-nCoV-2, have posed significant threats to human health and global economy through epidemics and pandemics.[1,2,3] Arguably, as a group, these are the most significant contemporary threat to human health in the domain of infectious diseases.[4].
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