Abstract
Transfer RNA (tRNA) is among the most highly modified biological molecules. To date, over 100 modifications have been documented in tRNA. Many are simple modifications, but a subset are hypermodifications that are introduced by complex, and in some cases, unknown enzymatic transformations. Our lab has been involved in deciphering the biosynthesis of queuosine and wybutosine, which are two broadly conserved hypermodified bases. This presentation will focus on recent biochemical and structural studies of the enzymes that catalyze key transformations in the biogenesis of these bases.Support or Funding InformationNIH GM72623This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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