Abstract
At present, the potential role of the AgNPs/endo-fullerene molecule metal nano-composite has been evaluated over the biosystems in-vitro. The intra-atomic configuration of the fullerene molecule (C60) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines and antimicrobial activity against a few human pathogens that have been augmented with the pristine surface plasmonic electrons and antibiotic activity of AgNPs. Furthermore, FTIR revealed the basic vibrational signatures at ~3300 cm−1, 1023 cm−1, 1400 cm−1 for O-H, C-O, and C-H groups, respectively, for the carbon and oxygen atoms of the C60 molecule. NMR studies exhibited the different footprints and magnetic moments at ~7.285 ppm, explaining the unique underlying electrochemical attributes of the fullerene molecule. Such unique electronic and physico-chemical properties of the caged carbon structure raise hope for applications into the drug delivery domain. The in-vitro dose-dependent application of C60 elicits a toxic response against both the breast adenocarcinoma cell lines and pathogenic microbes. That enables the use of AgNPs decorated C60 endo fullerene molecules to design an effective anti-cancerous drug delivery and antimicrobial agent in the future, bringing a revolutionary change in the perspective of a treatment regime.
Highlights
Fullerenes (C60) are caged zero-dimensional carbon nanostructures with their electrons confined in their native structure
The intra-atomic configuration of the fullerene molecule (C60) has been studied in-vitro for the anti-proliferative activity of human breast adenocarcinoma (MDA-MB-231) cell lines and antimicrobial activity against a few human pathogens that have been augmented with the pristine surface plasmonic electrons and antibiotic activity of AgNPs
It has been previously reported that C60 molecules can be prepared using bottom-up techniques using arch discharge, chemical route of Chemical Vapour Deposition (CVD), etc., where refined structures of C60 when visualized under High electron microscopy such as High-Resolution Transmission Electron Microscopy (HR-TEM), Field Emission-Scanning Electron Microscopy (FE-SEM) could be employed for visualizing and analyzing its native configurations
Summary
Fullerenes (C60) are caged zero-dimensional carbon nanostructures with their electrons confined in their native structure. It has been extensively reported that owing to the huge amount of surface electrons and surface energy on the nanoparticle surface, the effective interface of the silver nanoparticles with their biological counterparts increases exponentially [4]. Such silver nanoparticles and in composite forms with the interacting biological systems make the bio-nanocomposites a unique platform for several biological applications to disease diagnosis. The C60 molecule is a typical football-shaped structure with carbon (C) atoms in the pentagon and hexagon configurations. It has been speculated previously that when C60 molecules are tested in common cell lines, they exhibit differential toxicity responses when introduced at different dosages in in-vitro conditions [12,13,14,15,16,17]
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