Abstract
BI-3802 is a relatively new anticancer drug known to bind to the transcription repressor BCL6 and potently kill the most common form of cancer cells, B-cell lymphoma, found in the lymphatic system. Based on its structure we believe this small molecule drug can bind to DNA through intercalation. We use Optical tweezers to trap a single DNA molecule to explore the binding of this BI-3802 with DNA. Once we trap a single DNA molecule, we stretch the DNA and measure the tension in the DNA as a function of extension.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
