Abstract
Hearing loss becomes increasingly common with age and affects quality of life. Recently, scientists have published articles about the relationship between metabolic disease and hearing loss. Metabolic disease was previously found to be highly related to an increase in alkaline phosphatase. Thus, there may be an indirect relationship between alkaline phosphatase (ALP) and hearing loss. In this paper, we will demonstrate the relationship between ALP and hearing loss. We included 3877 National Health and Nutrition Examination Survey (NHANES) participants, who represent the noninstitutionalized civilian population in the United States from age 20 to age 69, and examined the association between ALP and frequency distributions of pure-tone air-condition (PTAC) thresholds. After adjusting for pertinent variables, the subjects who belonged to the higher quartiles of ALP tended to have worse hearing thresholds (pure tone average at high and low frequencies) than the first quartile of ALP (p < 0.001). The results showed a positive correlation between ALP and hearing loss, in both males and females (p < 0.001) and in subjects whose body mass indices (BMI) were less than 30 (p < 0.001). In conclusion, ALP may play a role in detecting hearing loss.
Highlights
The United States government has paid more attention to auditory healthcare recently due to the prevalence of adult hearing loss between ages 20 and 69
We investigated the association between alkaline phosphatase (ALP) and hearing loss using the National Health and Nutrition Examination Survey (NHANES) data from the year 1999 to 2004
diabetes mellitus (DM) status was significantly higher in the fourth quartile of ALP (P < 0.001)
Summary
After additional adjustment of models 1, 2 and 3, beta coefficients for ALP and high-PTA were 0.005, 0.005, and 0.005 respectively in men and 0.003, 0.004, and 0.004, respectively, in women (P for trend
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