Abstract
Objective: The objective of the investigation was to isolate mucilage from sweet basil seeds and explore its physicochemical properties for the development of pharmaceutical suspensions and surfactant-free stable emulsions.Methods: Possible applications of sweet basil seed mucilage in the pharmaceutical field for dosage form development are being explored. The physicochemical and functional properties of the mucilage from the seeds of the Ocimum basilicum L. (Sweet basil) have been investigated for stabilization of suspensions and emulsions. The following analyses were performed: FTIR spectroscopy, phytochemical tests, XRD, swelling and rheological studies.Results: The analyses showed that the mucilage is rich in glucose, mannose, and xylose. High swelling index values varying from 100±10 to 200±13%, high water-holding capacity of 97.5±2.4 g/g mucilage and reasonable oil holding capacity of the mucilage (13.2±1.3 g/g mucilage) makes it an ideal candidate for utilization as viscosifier and stabilizer of suspensions and surfactant-free emulsions. Adult and paediatric paracetamol suspension formulations with 1%w/v mucilage have exhibited flocculated nature and good stability owing to its high sedimentation volume(F= 0.85-0.98) and good redispersibility. Sunflower oil emulsions prepared with 0.25%w/v mucilage demonstrated emulsion stability index of 105.714 on 5th day and extremely low creaming rate of 0.0004 cm/h thus confirming maximum stability compared to emulsions developed with 0.3-0.5% w/v mucilage.Conclusion: The mucilage isolated from Ocimum basilicum L. seeds may be regarded as a functional biomaterial for pharmaceutical use to ensure quality and stability of liquid dosage forms.
Highlights
Excipients of synthetic origin are being widely used in the formulation of stable and effective pharmaceutical suspensions and emulsions as drug delivery vehicles
Differences in branching, molecular weight ranges, ionic charge of these non-starch polysaccharides have a profound influence on their water absorption capacity, water holding capacity, rheological and swelling behavior of their dispersions in aqueous medium and their applications in pharmaceutical field in design and formulation of sustained-release tablets, suspensions, emulsions, gels etc. [3]
Sweet basil seed i.e. Ocimum basilicum L. seeds used for mucilage extraction was purchased from the local market, Kolkata, West Bengal, India
Summary
Excipients of synthetic origin are being widely used in the formulation of stable and effective pharmaceutical suspensions and emulsions as drug delivery vehicles. Gums and mucilages are being currently investigated as natural excipients for conventional and novel dosage forms. Differences in branching, molecular weight ranges, ionic charge of these non-starch polysaccharides have a profound influence on their water absorption capacity, water holding capacity, rheological and swelling behavior of their dispersions in aqueous medium and their applications in pharmaceutical field in design and formulation of sustained-release tablets, suspensions, emulsions, gels etc. Natural gums from Irvingia gabonnsis, Albizia zygia, Grewia mollis, and Khaya grandifolia have been successful in improving the quality attributes of suspensions due to their ability to impart high viscosity to the dispersion medium on exposure to the aqueous medium by virtue of their swellability [4] Differences in branching, molecular weight ranges, ionic charge of these non-starch polysaccharides have a profound influence on their water absorption capacity, water holding capacity, rheological and swelling behavior of their dispersions in aqueous medium and their applications in pharmaceutical field in design and formulation of sustained-release tablets, suspensions, emulsions, gels etc. [3].
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