Exploring Pharmacological Mechanisms of Xiang Ju Tablets in the Treatment of Allergic Rhinitis via a Network Pharmacology Approach.

Kun Xia Hu,Bin Wang,Li Zhu Han,Xiao Song,Zhi Shu Tang,Xi Duan,Hong Ye Ju

doi:10.1155/2019/6272073

Abstract

In this study, allergic rhinitis (AR) disease targets and Xiang Ju tablet-associated targets were determined through the use of databases for the identification of putative therapeutic targets and then combined. After the production of a putative therapeutic target interaction network for Xiang Ju tablets against AR, topological analysis was used to determine the core targets of Xiang Ju tablets in AR treatment. For all putative therapeutic targets, analyses of biological function and pathway enrichment were performed to optimize the biological processes and key signaling pathways of Xiang Ju tablets in AR treatment. The top 5 therapeutic targets of Xiang Ju tablets in AR treatment were identified and included CXCL8, IL1B, IL6, IL10, and TNF. The biological processes, molecular functions, and cell composition related to the use of Xiang Ju tablets in AR treatment were predominantly associated with cytokine production, regulation of protein secretion, and regulation of peptide secretion; cytokine activity, cytokine receptor binding, and receptor ligand activity; and platelet alpha granule lumen, collagen-containing extracellular matrix, and platelet alpha granule. In addition, the top 64 key signaling pathways were identified.

Highlights

Allergic rhinitis (AR) is a very common disease that is most prevalent in children and adolescents
oral bioavailability (OB), drug likeness (DL), and Caco-2 thresholds were used to eliminate the compounds with duplicates and the compounds without target prediction data. e 145 active compounds from the 9 traditional Chinese medicines found in Xiang Ju tablets were searched in domestic and foreign literature databases and the Traditional Chinese Medicine Systems Pharmacology Database
145 ingredients from Xiang Ju tablets were selected for further research analysis, including 6 in Platycarya strobilacea Sieb. et Zucc, 6 in Prunellae Spica, in Astragali radix, 5 in Chrysanthemi Indici Flos, in Saposhnikoviae Radix, 14 in Magnoliae Flos, 71 in Glycyrrhizae radix et rhizoma, 7 in Chuanxiong Rhizoma, and 13 in Angelicae dahuricae radix, which were collected from TCMSP

Summary

Introduction

Allergic rhinitis (AR) is a very common disease that is most prevalent in children and adolescents. The treatments for AR are mainly drug therapy, including antihistamines, glucocorticoids, antileukotrienes, ketones, nasal decongestants, nasal anticholinergic drugs, and traditional Chinese medicine (TCM)

Methods

Results

Conclusion