Abstract
Exploring the connection between blood viscosity and liver in it have great significance for the detection and treatment of hyperlipidemic. Therefore, we designed a new near-infrared viscosity sensitive fluorescent probe Vis-LW based on the twisted intramolecular charge transfer mechanism. The probe exhibited a strong dependence on viscosity as well as good anti-interference performance. With the aid of Vis-LW, we successfully detected the viscosity changes in chloroquine induced cells and realized the diagnosis of diseases in hyperlipidemic mice by utilizing blood viscosity as a diagnostic indicator for hyperlipidemia. Not only that, the increased liver viscosity of hyperlipidemic mice was found for the first time, the reduced blood and liver viscosity after treatment with lipid-lowering drug fenofibrate was also tracked. This work provides a new method for the diagnosis of hyperlipidemia and offered a new idea on the research and treatment of hyperlipidemia in the future.
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