Abstract
Behcet Disease (BD) is a chronic systemic vasculitis, with its typical onset during young adulthood. Pediatric onset of the disease may occur in a limited number of cases, and frequently the diagnostic criteria applied for adult patients may not be fully satisfied. Therefore in the last years new diagnostic criteria for pediatric-onset BD have been developed (PED-BDIC). The pathogenesis of BD is still not clear, although various immunological hypotheses have been proposed. In this regard, evaluation of peripheral lymphocyte subsets as indicators of the underlying immunological disturbance has been performed in a limited number of adult BD patients, but data in pediatric BD patients are lacking.
Highlights
Behçet Disease (BD) is a chronic systemic vasculitis, with its typical onset during young adulthood
Pediatric onset of the disease may occur in a limited number of cases, and frequently the diagnostic criteria applied for adult patients may not be fully satisfied
Evaluation of peripheral lymphocyte subsets as indicators of the underlying immunological disturbance has been performed in a limited number of adult BD patients, but data in pediatric BD patients are lacking
Summary
Behçet Disease (BD) is a chronic systemic vasculitis, with its typical onset during young adulthood. Pediatric onset of the disease may occur in a limited number of cases, and frequently the diagnostic criteria applied for adult patients may not be fully satisfied. In the last years new diagnostic criteria for pediatric-onset BD have been developed (PED-BDIC). The pathogenesis of BD is still not clear, various immunological hypotheses have been proposed. In this regard, evaluation of peripheral lymphocyte subsets as indicators of the underlying immunological disturbance has been performed in a limited number of adult BD patients, but data in pediatric BD patients are lacking
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