Abstract
This paper explores intervention strategies for mitigating cellular senescence under microgravity, a significant challenge for space exploration and astronaut health. It delves into the mechanisms of accelerated cellular aging in microgravity, including oxidative stress and DNA damage, and proposes interventions ranging from pharmacological inhibitors to lifestyle modifications. The research underscores the potential of understanding aging in space to innovate strategies against aging and age-related diseases on Earth, thereby bridging space science and medical science for mutual advancements. Through a comprehensive review of current knowledge, potential mechanisms, impacts, and intervention strategies, this study aims to enhance astronaut health during prolonged missions and contribute to gerontology.
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