Abstract

FlyBase (flybase.org) is the primary online database of genetic, genomic, and functional information about Drosophila species, with a major focus on the model organism Drosophila melanogaster. The long and rich history of Drosophila research, combined with recent surges in genomic-scale and high-throughput technologies, mean that FlyBase now houses a huge quantity of data. Researchers need to be able to rapidly and intuitively query these data, and the QuickSearch tool has been designed to meet these needs. This tool is conveniently located on the FlyBase homepage and is organized into a series of simple tabbed interfaces that cover the major data and annotation classes within the database. This unit describes the functionality of all aspects of the QuickSearch tool. With this knowledge, FlyBase users will be equipped to take full advantage of all QuickSearch features and thereby gain improved access to data relevant to their research. © 2016 by John Wiley & Sons, Inc.

Highlights

  • FlyBase is the primary online database of genetic, genomic and functional information about Drosophila species, with a major focus on the model organism Drosophila melanogaster

  • Data are incorporated through curation of published research papers and via computational uploads of third-party datasets. Much of these data are partitioned across ~20 ‘data classes’ within FlyBase (Marygold et al, 2016; Table 1)

  • The tab allows a direct search of Human Disease Model Reports, which have been produced by FlyBase for those specific diseases for which Drosophila serves as a model. These reports include a summary of the human disease and implicated gene(s), information about the D. melanogaster model, and links to related data in FlyBase and at external sites, such as Online Mendelian Inheritance in Man (OMIM) (Amberger et al, 2015)

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Summary

Introduction

FlyBase is the primary online database of genetic, genomic and functional information about Drosophila species, with a major focus on the model organism Drosophila melanogaster. This tab (Fig. 1) performs a comprehensive case-insensitive search across most text fields associated with almost all FlyBase data classes. This displays the list of FlyBase data classes that are searched via the Simple tab and the number of matching records from each.

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