Abstract
Thymidylate synthase provides an essential function for the life of cells [8]. It provides the sole de novo pathway for synthesis of deoxythymidine monophosphate dTMP, a DNA base. Thus all organisms have thymidylate synthases with the exception with 1 or 2 algal species that obtain thymidine solely by salvage pathways. Thus thymidylate synthase is a target for antiproliferative drug design [25] aimed at pathogenic organisms in which selectivity versus host strains is important and as an antiproliferative in cancer [1,15,19,20,23,26].
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