Abstract
Tandem repeats (TRs) are associated with dis-ease genes, play an important role in evolution and are important in genomic organization and function. Much research has been done on de-scriptions of properties of tandem repeats, such as copy-number, period, etc, and correlation be-tween mutations within tandem repeats and dis-ease. This project aims to detect some differ-ences which may exist within the features of dif-ferent tandem repeats associated with disease in human whole-genome. The features of tandem repeats associated with diabetes genes were compared to the counterparts of non-diabetes disease genes.
Highlights
Repetitive DNA sequences have been identified in large quantities in both eukaryotic and prokaryotic genomes [2]
In some cases they can account for a large portion of the genome, for example, in the human genome they have been known to contribute around 40-50% of the total DNA sequence
In order to identify whether differences exist in quantity between tandem repeat-containing genes and nontandem repeat-containing genes of diabetes and nondiabetes disease genes, Table 3 was created
Summary
Repetitive DNA sequences have been identified in large quantities in both eukaryotic and prokaryotic genomes [2]. The existence of repetitive DNA in prokaryotes is limited, but it is found widely distributed throughout a large variety of eukaryotes, and can be found throughout the genome in both protein coding regions and inergenic regions. One of the reasons tandem repeats are of great interest is because of their nature to expand and contract unpredictably. It has been reported that microsatellites are biased towards expanding in length [15]. It has been reported that repeats within coding regions appear to have some kind of constraint hindering their expansion, whereas tandem repeats in untranslated regions do not appear to have these constraints, much higher copy numbers of these repeats are often present [16]
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