Exploring Aquasomes: A Promising Frontier in Nanotechnology-based Drug Delivery

Abstract

Nanotechnology has revolutionized the field of drug delivery, providing novel strategies to enhance drug efficacy and reduce side effects. Among these advancements, Aquasomes have emerged as promising nanocarriers, representing a unique class of colloidal delivery systems. Aquasomes are three-dimensional, self-assembling nanocomposites composed of a solid core coated with a layer of biocompatible polymers and stabilized by surfactants. Notably, the hydrophilic nature of Aquasomes allows them to encapsulate hydrophobic drugs, thereby overcoming solubility and stability challenges commonly associated with conventional drug formulations. The versatility of Aquasomes in encapsulating a wide range of drug molecules, including small molecules, proteins, and nucleic acids, expands their potential in various therapeutic areas. The applications of aquasomes are examined in targeted drug delivery, enabling site-specific release and minimizing off-target effects in this review. Moreover, the advantages of Aquasomes in improving drug stability and bioavailability are analyzed, and comparative assessments with other nanocarriers are presented. The potential challenges and ongoing research efforts to optimize Aquasome formulations for clinical translation are also discussed. Aquasomes offer a promising outlook for nanotechnology-based drug delivery, showing great potential in addressing existing limitations of conventional drug formulations. The constant progress in Aquasome research fuels optimism for their integration into mainstream therapeutics, revolutionizing medical treatments and patient outcomes.